Protein Details: Neuronal acetylcholine receptor subunit alpha-3

Protein ID

ICDB_Pro_0378

Protein Name

Neuronal acetylcholine receptor subunit alpha-3

Gene Name

chrna3

Organism

Carassius auratus (Goldfish)

Length

512 amino acids

AlphaFoldDB

AF-P18845-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Sequence

MNSASRITLFFLLTVLITQECLSSKGEDRLFRRLFRRYNQFIRPVENVSDPVTVEFEVSISQLVKVDEVNQIMETNLWLRHIWNDYKLKWLPAEFDGIEFIRVPSNKIWRPDIVLYNNAVGDFLVEDKTKALLKYDGTITWVPPAIFKSSCPMDITYFPFDYQNCSMKFGSWTYDKAKIDLVLIGSKVNLKDFWESGEWEIIDAPGYKHDIKYNCCEEIYPDITYSFYIRRLPLFYTINLIIPCLLISFLTILVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPMTHTMPSWVRTVFLRALPRVMLMRRPIDLSESSGKGGGEIAGSSGTGGGRGAEGKKMKSSASQQGAMNSLEFGEGKAALEGKKGGCPCHPIKEAIEGDCGKVSRQLTPQAINTVVTFSVVSPEIKQAIESVKYIAENMRSRNKAKEVEDDWKYVAMVIDRIFLWVFVLVCVLGTLGLFLQPLIGFFS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1002/j.1460-2075.1988.tb02852.x

RefSeq

NP_990146.1